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Are spirituality and science opposed to each other? First of all, just defining either concept seems almost hopeless at times. Describing them, on the other hand, is much easier, so let's start there.
Science is an approach to knowledge, a method. Scientists themselves will argue forever about a definition of science, but still agree that it is the most useful or productive method of understanding the world. Its essential characteristics are objective observation, the deriving of principles and "laws", and predictions based on these. (At the point where it produces things, it is also technology.)
It can be easily differentiated from religion by the fact that all of the knowledge it produces can be wrong. What is "known" through religions is typically sacred, and untouchable. Scientific knowledge, on the other hand, is always being overthrown or refined by further application of science. Faith is the cornerstone of religion, but evidence is for science.
This is why "creationist" science is bogus. A creationist "scientist" will not allow for his religiously based beliefs to be challenged by new evidence, and will openly tell you that his "faith" is more important to him than the evidence. He is only using the pretense of science to support his preconceived notions. On the other hand, many scientists have overturned even their own theories, despite their egos, because the essence of science is to go where the evidence leads you.
It would seem, then that spirituality and science contradict one another, but this isn't so. This would only be true if all spirituality was based on religious beliefs. Spirituality, however, can be simply seeking the higher levels of experience, asking the deepest questions, and seeking the true "self," which in no way makes it contrary to science. Science, in fact, being a productive method of discovering new truths, can be used for spiritual exploration and discovery.
Even a belief in God is not contrary to science, so long as it is based on ones experience rather than faith, and so long as it is open to change. A spiritual system of beliefs can be a convenient way of organizing and using our knowledge and experience, like many other scientific theories or paradigms. However, to peacefully co-exist with science, it must be open to change.
Spirituality then, can be forever seeking higher levels of experience, and looking for the answers to the deepest questions. Science can be forever used to help in this quest. Every answer raises questions that are deeper yet, so there is no extinguishment of spirituality by way of science. Spirituality is the quest, and science may be the most effective means of continuing it.